Cdk5r1 Polyclonal Antibody for Rat(Rattus norvegicus) | EIAab.comCdk5r1 Polyclonal Antibody for Rat(Rattus norvegicus)

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Cdk5r1 (Gene name),

Cyclin-dependent kinase 5 activator 1 (Protein name ), CD5R1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Cdk5r1(Cdk5r);

Protein name:

Cyclin-dependent kinase 5 activator 1(CDK5 activator 1);

Alternative:

TPKII regulatory subunit;Cyclin-dependent kinase 5 regulatory subunit 1;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Heterodimer composed of CDK5 and CDK5R (p25) and macromolecular complex composed of at least CDK5, CDK5R (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity (By similarity). Interacts with RASGRF2. Interacts with EPHA4 and NGEF; may mediate the activation of NGEF by EPHA4.

Function:

p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII.

Subcellular Location:

Cyclin-dependent kinase 5 activator 1, p25 Nucleus Cytoplasm perinuclear region The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions.

Protein Attributes:

Sequence length:

307

Sequence:

50:

100:

150:

200:

250:

300:

307:

LLLGLDR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF03261

UniGene:

Rn.11213

SMR:

P61810

STRING:

10116.ENSRNOP00000062473

KEGG:

rno:116671

String:

P61810

Uniprot:

P61810

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ELISA Kit for Rat CDK5 activator 1

Cat.:

E15082r

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96T

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ELISA Kit for Rat CDK5 activator 1

Cat.:

E15082h

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96T

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ELISA Kit for Rat CDK5 activator 1

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ELISA Kit for Rat CDK5 activator 1

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CLIA Kit for Rat CDK5 activator 1

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CLIA Kit for Rat CDK5 activator 1

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CLIA Kit for Rat CDK5 activator 1

Cat.:

U15082r

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MSDS:

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Packing:

96T

CLIA Kit for Rat CDK5 activator 1

Cat.:

U15082h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat CDK5 activator 1

Monoclonal Antibody for Rat CDK5 activator 1

Protein for Rat CDK5 activator 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Phosphorylation of the high molecular weight neurofilament protein (NF-H) by Cdk5 and p35."
Sun D. , Leung C.L. , Liem R.K.H.
J. Biol. Chem.271:14245-14250(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
2.

"Processing of cdk5 activator p35 to its truncated form (p25) by calpain in acutely injured neuronal cells."
Nath R. , Davis M. , Probert A.W. , Kupina N.C. , Ren X. , Schielke G.P. , Wang K.K.
Biochem. Biophys. Res. Commun.274:16-21(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC CLEAVAGE BY CALPAIN
3.

"p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent extracellular signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons."
Kesavapany S. , Amin N. , Zheng Y.-L. , Nijhara R. , Jaffe H. , Sihag R. , Gutkind J.S. , Takahashi S. , Kulkarni A. , Grant P. , Pant H.C.
J. Neurosci.24:4421-4431(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RASGRF2
4.

"Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation."
Kamei H. , Saito T. , Ozawa M. , Fujita Y. , Asada A. , Bibb J.A. , Saido T.C. , Sorimachi H. , Hisanaga S.
J. Biol. Chem.282:1687-1694(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-8 AND THR-138;MUTAGENESIS OF THR-138
5.

"Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism."
Fu W.Y. , Chen Y. , Sahin M. , Zhao X.S. , Shi L. , Bikoff J.B. , Lai K.O. , Yung W.H. , Fu A.K. , Greenberg M.E. , Ip N.Y.
Nat. Neurosci.10:67-76(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPHA4

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